Interação medicamentosa entre anticoncepcionais orais e Carbamazepina, Topiramato e Oxcarbazepina

Authors

  • Nathalya Tesch Brazil Faculdade QI Brasil - FAQI
  • Juarez Mazzuca Júnior Faculdade QI Brasil - FAQI

Keywords:

Understanding about drug interaction, Carbamazepina, Topiramato, Oxcarbazepina, Oral Contraceptives.

Abstract

The use of antiepileptic drugs is a necessary resource in the treatment of epilepsy, since there is an electrical mismatch within the brain. Thus, some drugs act in a way to prevent the action potential from happening in the wrong way. Although there are
currently several classes of drugs, adverse effects in all classes are clinically relevant. These drugs have, in addition to several adverse effects, drug interactions. This is due to their metabolism, involving several enzymes of the cytochrome P450 complex. Within these drug interactions, it draws attention, which involves oral contraceptives. This is relevant, as they have concentrations that decrease in the presence of antiepileptics, and may not reach the minimum therapeutic concentrations necessary to inhibit a pregnancy. Thus, the investigation of drug interactions involving antiepileptic drugs becomes of high importance, as it can cause serious adverse effects, in addition to an unwanted pregnancy, when referring to oral contraceptives.

Author Biographies

Nathalya Tesch Brazil, Faculdade QI Brasil - FAQI

Doutoranda no Programa de Pós-Graduação em Ciências Farmacêuticas/UFRGS.

Juarez Mazzuca Júnior, Faculdade QI Brasil - FAQI

Licenciado em Física UFRGS, mestrado em Sensoriamento Remoto UFRGS, especialista em Geometria Analítica e Espacial (CESUCA) e ex graduando em Psicologia (CESUCA). Prof. Concursado de Física da Escola Técnica Estadual José Feijó - PORTO ALEGRE.

Published

2020-12-23

How to Cite

Tesch Brazil, N., & Mazzuca Júnior, J. (2020). Interação medicamentosa entre anticoncepcionais orais e Carbamazepina, Topiramato e Oxcarbazepina. REFAQI - REVISTA DE GESTÃO EDUCAÇÃO E E TECNOLOGIA, 8(2), 17. Retrieved from https://refaqi.faqi.edu.br/index.php/refaqi/article/view/59